Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections.

ABSTRACT: Vaccines against parasites have lagged centuries behind those against viral and bacterial infections, despite the devastating morbidity and widespread effects of parasitic diseases across the globe. One of the greatest hurdles to parasite vaccine development has been the lack of vaccine strategies able to elicit the complex and multifaceted immune responses needed to abrogate parasitic persistence. Viral vectors, especially adenovirus (AdV) vectors, have emerged as a potential solution for complex disease targets, including HIV, tuberculosis, and parasitic diseases, to name a few. AdVs are highly immunogenic and are uniquely able to drive CD8+ T cell responses, which are known to be correlates of immunity in infections with most protozoan and some helminthic parasites. This review presents

SUBMITTER: Koger-Pease C 

PROVIDER: S-EPMC10058461 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature