Tropism of Puumala orthohantavirus and Endoparasite Coinfection in the Bank Vole Reservoir.

ABSTRACT: In Europe, most cases of human hantavirus disease are caused by Puumala orthohantavirus (PUUV) transmitted by bank voles (Clethrionomys glareolus, syn. Myodes glareolus), in which PUUV causes inconspicuous infection. Little is known about tropism and endoparasite coinfections in PUUV-infected reservoir and spillover-infected rodents. Here, we characterized PUUV tropism, pathological changes and endoparasite coinfections. The voles and some non-reservoir rodents were examined histologically, immunohistochemically, by in situ hybridization, indirect IgG enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. PUUV RNA and anti-PUUV antibodies were detected simultaneously in a large proportion of the bank voles, indicating persistent infectio

SUBMITTER: Schlohsarczyk EK 

PROVIDER: S-EPMC10058470 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature