An Individuality of Response to Cannabinoids: Challenges in Safety and Efficacy of Cannabis Products.

ABSTRACT: Since legalization, cannabis/marijuana has been gaining considerable attention as a functional ingredient in food. ∆-9 tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids are key bioactive compounds with health benefits. The oral consumption of cannabis transports much less hazardous chemicals than smoking. Nevertheless, the response to cannabis is biphasically dose-dependent (hormesis; a low-dose stimulation and a high-dose inhibition) with wide individuality in responses. Thus, the exact same dose and preparation of cannabis may be beneficial for some but toxic to others. The purpose of this review is to highlight the concept of individual variations in response to cannabinoids, which leads to the challenge of establishing standard safe doses of cannabis products for th

SUBMITTER: Kitdumrongthum S 

PROVIDER: S-EPMC10058560 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature