Safety and Immunogenicity of Recombinant Bacille Calmette-Guerin Strain VPM1002 and Its Derivatives in a Goat Model.

ABSTRACT: A more effective vaccine against tuberculosis than Bacille Calmette-Guérin (BCG) is urgently needed. BCG derived recombinant VPM1002 has been found to be more efficacious and safer than the parental strain in mice models. Newer candidates, such as VPM1002 Δpdx1 (PDX) and VPM1002 ΔnuoG (NUOG), were generated to further improve the safety profile or efficacy of the vaccine. Herein, we assessed the safety and immunogenicity of VPM1002 and its derivatives, PDX and NUOG, in juvenile goats. Vaccination did not affect the goats' health in regards to clinical/hematological features. However, all three tested vaccine candidates and BCG induced granulomas at the site of injection, with some of the nodules developing ulcerations approximately one month post-vaccination. Viable va

SUBMITTER: Figl J 

PROVIDER: S-EPMC10058566 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature