Biodegradable Block Poly(ester amine)s with Pendant Hydroxyl Groups for Biomedical Applications.

ABSTRACT: The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on ¹H NMR, FTIR, GPC

SUBMITTER: Smigiel-Gac N 

PROVIDER: S-EPMC10058592 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature