The Genetic Basis of Childhood Obesity: A Systematic Review.

ABSTRACT: Overweight and obesity in childhood and adolescence represents one of the most challenging public health problems of our century owing to its epidemic proportions and the associated significant morbidity, mortality, and increase in public health costs. The pathogenesis of polygenic obesity is multifactorial and is due to the interaction among genetic, epigenetic, and environmental factors. More than 1100 independent genetic loci associated with obesity traits have been currently identified, and there is great interest in the decoding of their biological functions and the gene-environment interaction. The present study aimed to systematically review the scientific evidence and to explore the relation of single-nucleotide polymorphisms (SNPs) and copy number variants (CNVs) with changes in b

SUBMITTER: Vourdoumpa A 

PROVIDER: S-EPMC10058966 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature