Membrane-Based Solvent Exchange Process for Purification of API Crystal Suspensions.

ABSTRACT: Bottom-up approaches to producing aqueous crystal suspensions of active pharmaceutical ingredients (APIs), such as anti-solvent crystallisation, are gaining interest as they offer better control over surface properties compared to top-down approaches. However, one of the major challenges that needs to be addressed is the removal of organic solvents after the crystallisation step due to strict limitations regarding human exposure. Within this work, we investigated a process concept for the removal of solvent (i.e., ethanol) from the API crystal suspension using membrane-based diafiltration. A four-stage diafiltration process successfully reduced the ethanol concentration in the API (here, naproxen) crystal suspension below 0.5 wt% (the residual solvent limit as per ICH guidelines) with a wa

SUBMITTER: Anjum F 

PROVIDER: S-EPMC10058991 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature