Radio Wave-Activated Chemotherapy-A Novel Nanoparticle Thermoresponsive Copolymer Drug Delivery Platform.

ABSTRACT: Radio waves are highly penetrating, non-ionizing, and cause minimal damage to surrounding tissues. Radio wave control of drug release has been achieved using a novel thermoresponsive copolymer bound to a superparamagnetic iron oxide nanoparticle (SPION) core. A NIPAM-acrylamide-methacrolein copolymer underwent a coil-to-globular structure phase change upon reaching a critical temperature above the human body temperature but below hyperthermic temperatures. The copolymer was covalently bound to SPIONs which increase in temperature upon exposure to radio waves. This effect could be controlled by varying input energies and frequencies. For controlled drug release, proteins were bound via aldehyde groups on the copolymer and amine groups on the protein. The radio wave-induced heating of the co

SUBMITTER: White BD 

PROVIDER: S-EPMC10059094 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature