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Tetrodotoxin Decreases the Contractility of Mesenteric Arteries, Revealing the Contribution of Voltage-Gated Na⁺ Channels in Vascular Tone Regulation.

ABSTRACT: Tetrodotoxin (TTX) poisoning through the consumption of contaminated fish leads to lethal symptoms, including severe hypotension. This TTX-induced hypotension is likely due to the downfall of peripheral arterial resistance through direct or indirect effects on adrenergic signaling. TTX is a high-affinity blocker of voltage-gated Na⁺ (Na_V) channels. In arteries, Na_V channels are expressed in sympathetic nerve endings, both in the intima and media. In this present work, we aimed to decipher the role of Na_V channels in vascular tone using TTX. We first characterized the expression of Na_V channels in the aorta, a model of conduction arteries, and in mesenteric arteries (MA), a model of resistance arteries, in C57Bl/6J mice, by Western blot

SUBMITTER: Park J

PROVIDER: S-EPMC10059581 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Tetrodotoxin Decreases the Contractility of Mesenteric Arteries, Revealing the Contribution of Voltage-Gated Na⁺ Channels in Vascular Tone Regulation.

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Tetrodotoxin Decreases the Contractility of Mesenteric Arteries, Revealing the Contribution of Voltage-Gated Na+ Channels in Vascular Tone Regulation.

OmicsDI is part of the ELIXIR infrastructure

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Tetrodotoxin Decreases the Contractility of Mesenteric Arteries, Revealing the Contribution of Voltage-Gated Na⁺ Channels in Vascular Tone Regulation.