Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia.

ABSTRACT: Since suicide and suicidal behavior are considered highly heritable phenotypes, the identification of genetic markers that can predict suicide risk is a clinically important topic. Several genes studied for possible associations between genetic polymorphisms and suicidal behaviors had mostly inconsistent and contradictory findings. The aim of this case-control study was to evaluate the associations between completed suicide and polymorphisms in genes BDNF (rs6265, rs962369), SLC6A4 (5-HTTLPR), and FTO (rs9939609) in relation to sex and BMI. We genotyped 119 completed suicide victims and 137 control subjects that were age, sex, and ethnicity matched. A significant association with completed suicide was found for BDNF rs962369. This variant could play a rol

SUBMITTER: Bednarova A 

PROVIDER: S-EPMC10059737 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature