Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.

ABSTRACT: With the spread of SARS-CoV-2 throughout the globe causing the COVID-19 pandemic, the threat of zoonotic transmissions of coronaviruses (CoV) has become even more evident. As human infections have been caused by alpha- and beta-CoVs, structural characterization and inhibitor design mostly focused on these two genera. However, viruses from the delta and gamma genera also infect mammals and pose a potential zoonotic transmission threat. Here, we determined the inhibitor-bound crystal structures of the main protease (M^pro) from the delta-CoV porcine HKU15 and gamma-CoV SW1 from the beluga whale. A comparison with the apo structure of SW1 M^pro, which is also presented here, enabled the identification of structural arrangements upon inhibitor binding at the active site. Th

SUBMITTER: Zvornicanin SN 

PROVIDER: S-EPMC10059799 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature