Development of an IgY-Based Treatment to Control Bovine Coronavirus Diarrhea in Dairy Calves.

ABSTRACT: Bovine Coronavirus (BCoV) is a major pathogen associated with neonatal calf diarrhea. Standard practice dictates that to prevent BCoV diarrhea, dams should be immunized in the last stage of pregnancy to increase BCoV-specific antibody (Ab) titers in serum and colostrum. For the prevention to be effective, calves need to suck maternal colostrum within the first six to twelve hours of life before gut closure to ensure a good level of passive immunity. The high rate of maternal Ab transfer failure resulting from this process posed the need to develop alternative local passive immunity strategies to strengthen the prevention and treatment of BCoV diarrhea. Immunoglobulin Y technology represents a promising tool to address this gap. In this study, 200 laying hens were immunized with BCoV to obt

SUBMITTER: Bok M 

PROVIDER: S-EPMC10059803 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature