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Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity.

ABSTRACT: A new bicyclic nonene, tsaokoic acid (1), was isolated from the fruits of Amomum tsao-ko, together with three known compounds (2-4). The structure of 1 was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds 2-4 were identified as tsaokoin, vanillin, and tsaokoarylone, respectively, by comparing their NMR spectra with previously reported data. Compounds 1-4 showed possible inhibitory activity against acetylcholinesterase (AChE) in silico molecular docking simulations. They were submitted to in vitro assay system and exhibited moderate inhibitory activity with IC₅₀ values of 32.78, 41.70, 39.25, and 31.13 μM, respectively.

SUBMITTER: Kim H

PROVIDER: S-EPMC10059965 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity.

Kim Hyunyoung H Lee Hwaryeong H Jung Hee Jin HJ Noh Sang Gyun SG Youn Isoo I Kwak Hyunkyung H Lee Yeju Y Nam Sang-Jip SJ Kang Soosung S Chung Hae Young HY Seo Eun Kyoung EK

Molecules (Basel, Switzerland) 20230313 6

A new bicyclic nonene, tsaokoic acid (1), was isolated from the fruits of Amomum tsao-ko, together with three known compounds (2-4). The structure of 1 was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds 2-4 were identified as tsaokoin, vanillin, and tsaokoarylone, respectively, by comparing their NMR spectra with previously reported data. Compounds 1-4 showed possible inhibitory activity agai ...[more]

PMID: 36985573

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