Assessment of Lipophilicity Parameters of Antimicrobial and Immunosuppressive Compounds.

ABSTRACT: Lipophilicity in addition to the solubility, acid-base character and stability is one of the most important physicochemical parameters of a compound required to assess the ADMET properties (absorption, distribution, metabolism, excretion and toxicity) of a bioactive molecule. Therefore, the subject of this work was to determine the lipophilicity parameters of selected antimicrobial and immunosuppressive compounds such as delafloxacin, linezolid, sutezolid, ceftazidime, everolimus and zotarolimus using thin-layer chromatography in reversed phase system (RP-TLC). The chromatographic parameters of lipophilicity (R_MW) for tested compounds were determined on different stationary phases: RP18F₂₅₄, RP18WF₂₅₄ and RP2F₂₅₄ using ethanol, acetonitrile, and

SUBMITTER: Wardecki D 

PROVIDER: S-EPMC10059999 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature