New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management.

ABSTRACT: Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are considered viable options since they mimic the skin structure and promote autolysis and growth factor synthesis. Unfortunately, hydrogels are associated with several drawbacks, such as low mechanical strength and the potential toxicity of byproducts released after crosslinking reactions. To overcome these aspects, in this study new smart chitosan (CS)-based hydrogels were developed, using oxidized chitosan (oxCS) and hyaluronic acid (oxHA) as nontoxic crosslinkers. Three active product ingredients (APIs) (fusidic acid, allantoin, and coenzyme

SUBMITTER: Tatarusanu SM 

PROVIDER: S-EPMC10060009 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature