HLA-A Locus is Associated With Sepsis and Septic Shock After Traumatic Injury.

ABSTRACT:

Objective

Determine whether variation in the HLA region is associated with the development of post-traumatic sepsis and septic shock.

Background

Sepsis-related deaths remain a major source of mortality after traumatic injury. Genetic characteristics may contribute to susceptibility to adverse outcomes including sepsis and septic shock. Recent advances in next-generation sequencing technology now allow comprehensive genotyping of the HLA region.

Methods

White adult trauma patients requiring more than 2 days of mechanical ventilation underwent HLA genotyping, and were followed for the development of sepsis and septic shock. Odds ratios (OR) for the associations between our outcomes and HLA variants were estimated, a correction for multiple comparisons was applied, and s

SUBMITTER: Horn DL 

PROVIDER: S-EPMC10060028 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature