Safety and immunogenicity of heterologous ChAdOx1-nCoV19 and BNT162b2 vaccination: A meta-analysis of the heterologous COVID-19 vaccination outcomes.

ABSTRACT:

Introduction

Here, we systematically assessed the safety and immunogenicity of the heterologous ChAd/BNT vaccination regimens.

Materials and methods

We evaluated the immunogenicity by the geometric mean titers ratio (GMTR) of the neutralizing antibody and anti-spike IgG. The safety of heterologous ChAd/BNT vaccination was evaluated using the pooled risk ratios (RRs) calculated by the random-effects model about the adverse events. Our study was registered with PROSPERO, CRD42021265165.

Results

Eleven studies were included in the analyses. Compared to the homologous ChAd/ChAd vaccination, the heterologous ChAd/BNT vaccination showed significantly higher immunogenicity in terms of the neutralizing antibody and GMTR of anti-spike IgG, but at the same time displayed higher

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10060199 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature