A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases.

ABSTRACT: Treatment effects are often anticipated to vary across groups of patients with different baseline risk. The Predictive Approaches to Treatment Effect Heterogeneity (PATH) statement focused on baseline risk as a robust predictor of treatment effect and provided guidance on risk-based assessment of treatment effect heterogeneity in a randomized controlled trial. The aim of this study is to extend this approach to the observational setting using a standardized scalable framework. The proposed framework consists of five steps: (1) definition of the research aim, i.e., the population, the treatment, the comparator and the outcome(s) of interest; (2) identification of relevant databases; (3) development of a prediction model for the outcome(s) of interest; (4) estimation of relative and absolute

SUBMITTER: Rekkas A 

PROVIDER: S-EPMC10060247 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature