P130Cas is required for androgen-dependent postnatal development regulation of submandibular glands.

ABSTRACT: Salivary glands develop through epithelial-mesenchymal interactions and are formed through repeated branching. The Crk-associated substrate protein (p130Cas) serves as an adapter that forms a complex with various proteins via integrin and growth factor signaling, with important regulatory roles in several essential cellular processes. We found that p130Cas is expressed in ductal epithelial cells of the submandibular gland (SMG). We generated epithelial tissue-specific p130Cas-deficient (p130Cas^Δepi-) mice and aimed to investigate the physiological role of p130Cas in the postnatal development of salivary glands. Histological analysis showed immature development of granular convoluted tubules (GCT) of the SMG in male p130Cas^Δepi- mice. Immunofluorescence staining showed

SUBMITTER: Gao J 

PROVIDER: S-EPMC10060253 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature