Effect of scan-time shortening on the ¹¹C-PHNO binding potential to dopamine D₃ receptor in humans and test-retest reliability.

ABSTRACT:

Objective

¹¹C-PHNO is a PET radioligand most specific to dopamine D₃ receptor (D₃R). The long scan duration of 120 min used in quantification of ¹¹C-PHNO binding to D₃R in previous studies is challenging to subjects. The main objective of this study was to investigate the effects of shorter scan times on the binding of ¹¹C-PHNO to D₃R and test-retest reliability using the latest digital whole-body PET system.

Methods

Two 120-min ¹¹C-PHNO brain scans were performed in 7 healthy subjects using a digital whole-body PET/CT. The binding potential relative to non-displaceable tracer in the tissue (BP_ND) of D₃R-rich regions: the pallidum, ventral striatum (VST), substantia

SUBMITTER: Matsunaga K 

PROVIDER: S-EPMC10060283 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature