Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.

ABSTRACT:

Introduction

Increased exposure to risk factors in the young and healthy contributes to arterial changes, which may be accompanied by an altered metabolism.

Objectives

To increase our understanding of early metabolic alterations and how they associate with markers of arterial stiffness, we profiled urinary metabolites in young adults with cardiovascular disease (CVD) risk factor(s) and in a control group without CVD risk factors.

Methods

We included healthy black and white women and men (N = 1202), aged 20-30 years with a detailed CVD risk factor profile, reflecting obesity, physical inactivity, smoking, excessive alcohol intake, masked hypertension, hyperglycemia, dyslipidemia and low socio-economic status, forming the CVD risk group (N = 1036) and the control group

SUBMITTER: du Toit WL 

PROVIDER: S-EPMC10060307 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature