Urinary complement proteins are increased in children with IgA vasculitis (Henoch-Schonlein purpura) nephritis.

ABSTRACT:

Background

Children with immunoglobulin A vasculitis (IgAV Henoch-Schönlein purpura) frequently encounter nephritis (IgAV-N) with 1-2% risk of kidney failure. The pathophysiology of IgAV-N is not fully understood with speculation that complement may contribute. The aim of this study was to identify whether urinary complement proteins are increased in children with IgAV-N.

Methods

A cross-sectional prospective cohort of children with IgAV were recruited together with controls including healthy children and children with systemic lupus erythematosus (SLE). Patients were subdivided according to the presence of nephritis. Urinary C3, C4, C5, and C5a were measured by enzyme-linked immunosorbent assay (ELISA) and corrected for urinary creatinine.

Results

The study included

SUBMITTER: Wright RD 

PROVIDER: S-EPMC10060309 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature