Chronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL/6 mice.

ABSTRACT: Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecular effects of stress in this context. Here, we investigate the immediate effect of a stress period on energy metabolism in Musculus gastrocnemius in our established C57BL/6 chronic variable stress (Cvs) mouse model. Cvs decreased lean body mass despite increased energy intake, reduced circadian energy expenditure (EE), and substrate utilization. Cvs altered the proteome of metabolic components but not of the oxidative phosphorylation system (OXPHOS), or other mitochondrial structural components

SUBMITTER: Nikolic A 

PROVIDER: S-EPMC10060325 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature