Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons.

ABSTRACT:

Background

Guanfacine (an alpha-2A receptor agonist) is a commonly used drug with recognized efficacy in the treatment of attention deficit hyperactivity disorder (ADHD). This study aimed to assess the effects of guanfacine on short-lasting (interictal) epileptiform discharges in cortical neurons. Moreover, we assessed the effects of guanfacine on voltage-gated sodium currents.

Methods

We conducted patch-clamp recordings in prefrontal cortex pyramidal neurons obtained from young rats. Interictal epileptiform events were evoked in cortical slices in a zero magnesium proepileptic extracellular solution with an elevated concentration of potassium ions.

Results

Interictal epileptiform discharges were spontaneous depolarisations, which triggered action potentials. Guanfaci

SUBMITTER: Pasierski M 

PROVIDER: S-EPMC10060326 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature