Expression of immune checkpoint molecules on adult and neonatal T-cells.

ABSTRACT: Term and especially preterm neonates are much more susceptible to serious bacterial infections than adults. But not only the susceptibility to infection is increased in neonates, but also their risk for developing post-inflammatory diseases such as bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL). This may be due to an impaired ability to terminate inflammation. In the study presented here, we aimed to investigate the proliferative response and the expression of immune-checkpoint molecules (ICM) and activation markers on neonatal T-cells in comparison to adult T-cells with the hypothesis that an increased activation of neonatal T-cells may contribute to the failure of inflammation resolution observed in neonates. We show that neonatal CD4⁺ and CD8⁺

SUBMITTER: Dietz S 

PROVIDER: S-EPMC10060332 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature