High FAM111B expression predicts aggressive clinicopathologic features and poor prognosis in ovarian cancer.

ABSTRACT:

Backgrounds

Ovarian cancer (OC) is the second most common gynecological tumor with the highest mortality rate worldwide. High FAM111B expression has been reported as a predictor of poor prognosis in other cancers, but its correlation with OC has not been reported.

Methods

Immunohistochemistry of tissue microarrays was performed to detect FAM111B expression levels in 141 OC patient tissues. The prognostic value of FAM111B was determined by Kaplan-Meier survival analysis, and correlations between FAM111B expression and clinicopathologic features were investigated by the Clu-square test. The significance of FAM111B expression was verified bioinformatically using the Gene Expression Omnibus database. Protein-protein interaction were performed to explore downstream mechanisms of

SUBMITTER: Wei F 

PROVIDER: S-EPMC10060368 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature