Ontology highlight
ABSTRACT:
SUBMITTER: Cope EC
PROVIDER: S-EPMC10060401 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Cope Elise C EC Wang Samantha H SH Waters Renée C RC Gore Isha R IR Vasquez Betsy B Laham Blake J BJ Gould Elizabeth E
Nature communications 20230329 1
Mutation or deletion of the SHANK3 gene, which encodes a synaptic scaffolding protein, is linked to autism spectrum disorder and Phelan-McDermid syndrome, conditions associated with social memory impairments. Shank3B knockout mice also exhibit social memory deficits. The CA2 region of the hippocampus integrates numerous inputs and sends a major output to the ventral CA1 (vCA1). Despite finding few differences in excitatory afferents to the CA2 in Shank3B knockout mice, we found that activation o ...[more]