Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors.

ABSTRACT: Studies in multiple organisms have shown that aging is accompanied by several molecular phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based processes such as transcription, alterations in chromatin modifications could impact the transcriptome and function of aging cells. In flies, as in mammals, the aging eye undergoes changes in gene expression that correlate with declining visual function and increased risk of retinal degeneration. However, the causes of these transcriptome changes are poorly understood. Here, we profiled chromatin marks associated with active transcription in the aging Drosophila eye to understand how chromatin modulates transcriptional outputs. We found that both H3K4me3 and H3K36me3 globally decrease across all actively expressed ge

SUBMITTER: Jauregui-Lozano J 

PROVIDER: S-EPMC10060402 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature