Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging.

ABSTRACT: Higher neuroticism is a risk factor for Alzheimer's disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain region to develop abnormal tau. We examined relationships among the "Big 5" personality traits, LC catecholamine synthesis capacity measured with [¹⁸F]Fluoro-m-tyrosine PET, and tau burden measured with [¹⁸F]Flortaucipir PET in cognitively normal older adults (n = 47). β-amyloid (Aβ) status was determined using [¹¹C]Pittsburgh compound B PET (n = 14 Aβ positive). Lower LC catecholamine synthesis capacity was associated with higher neuroticism, more depressive symptom

SUBMITTER: Parent JH 

PROVIDER: S-EPMC10060440 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature