Stereotactical normalization with multiple templates representative of normal and Parkinson-typical reduction of striatal uptake improves the discriminative power of automatic semi-quantitative analysis in dopamine transporter SPECT.

ABSTRACT:

Background

The specific binding ratio (SBR) of ¹²³I-FP-CIT in the putamen is widely used to support the interpretation of dopamine transporter (DAT) SPECT. Automatic methods for computation of the putamen SBR often include stereotactical normalization of the individual DAT-SPECT image to an anatomical standard space. This study compared using a single ¹²³I-FP-CIT template image as target for stereotactical normalization versus multiple templates representative of normal and different levels of Parkinson-typical reduction of striatal ¹²³I-FP-CIT uptake.

Methods

1702 clinical ¹²³I-FP-CIT SPECT images were stereotactically normalized (affine) to the anatomical space of the Montreal Neurological Institute (MNI) with SPM12 either using

SUBMITTER: Apostolova I 

PROVIDER: S-EPMC10060476 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature