Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions.

ABSTRACT: Levocetirizine dihydrochloride (LCTZ) is a second-generation antihistamine known for its efficacy without sedation. However, the binding mechanism with plasma protein which makes it devoid of sedative effects is yet to be uncovered. In this study, we elucidated thermodynamic parameters of solute-solvent and solute-cosolute interactions between LCTZ, and the amino acids l-alanine (Ala) and l-glutamine (Gln) in aqueous solutions. The volumetric and conductance parameters were calculated using the experimental density and conductance data of aqueous solutions of Ala and Gln (concentration range of 0.02-0.20 mol kg^-1) and LCTZ (concentration range of 0.01, 0.07, and 0.13 mol kg^-1) at 298.15, 303.15, 308.15, and 313.15 K. Volumetric analysis study revealed that the apparen

SUBMITTER: Zolkiflee NF 

PROVIDER: S-EPMC10060571 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature