Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma.

ABSTRACT: The identification of intestinal dysbiosis in patients with neurological and psychiatric disorders has highlighted the importance of gut-brain communication, and yet the question regarding the identity of the components responsible for this cross-talk remains open. We previously reported that relapsing remitting multiple sclerosis patients treated with dimethyl fumarate have a prominent depletion of the gut microbiota, thereby suggesting that studying the composition of plasma and CSF samples from these patients may help to identify microbially derived metabolites. We used a functional xenogeneic assay consisting of cultured rat neurons exposed to CSF samples collected from multiple sclerosis patients before and after dimethyl fumarate treatment to assess neurotoxicity and then conducted a

SUBMITTER: Ntranos A 

PROVIDER: S-EPMC10060700 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature