A strategy to reduce fraction number in peripheral lung stereotactic ablative body radiotherapy.

ABSTRACT:

Background and purpose

Hypo-fractionated lung Stereotactic Ablative Body Radiotherapy (SABR) has often been avoided when tumours are close to the chest wall. Our strategic objective was the reduction of fraction number, while maintaining target biological effective dose coverage without increasing chest wall toxicity (CWT) predictors.

Materials and methods

Twenty previously treated lung SABR patients were stratified into four cohorts according to distance from PTV to the chest wall, <1 cm, <0.5 cm, overlapping up to 0.5 cm and 1.0 cm. For each patient, four plans were created; a chest wall optimised plan for 54 Gy in 3 fractions, the clinical plan re-prescribed for 55 Gy in 5, 48 Gy in 3 and 45 Gy in 3 fractions.

Results

For a PTV distance of 0.5-0.0 cm, a reduction o

SUBMITTER: O'Keeffe S 

PROVIDER: S-EPMC10060739 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature