Coevolutionary signals in metabotropic glutamate receptors capture residue contacts and long-range functional interactions.

ABSTRACT: Upon ligand binding to a G protein-coupled receptor, extracellular signals are transmitted into a cell through sets of residue interactions that translate ligand binding into structural rearrangements. These interactions needed for functions impose evolutionary constraints so that, on occasion, mutations in one position may be compensated by other mutations at functionally coupled positions. To quantify the impact of amino acid substitutions in the context of major evolutionary divergence in the G protein-coupled receptor subfamily of metabotropic glutamate receptors (mGluRs), we combined two phylogenetic-based algorithms, Evolutionary Trace and covariation Evolutionary Trace, to infer potential structure-function couplings and roles in mGluRs. We found a subset of evolutionarily important

SUBMITTER: Huh E 

PROVIDER: S-EPMC10060750 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature