Increased Non-MAIT CD161⁺CD8⁺ T Cells Display Pathogenic Potential in Chronic HBV Infection.

ABSTRACT:

Background & aims

CD161-expressing CD8⁺ T cells consist of mucosal-associated invariant T cells with semi-invariant T-cell receptor (TCR) use and non-mucosal-associated invariant T CD161⁺CD8⁺ T cells with polyclonal TCR repertoire. Although CD161⁺CD8⁺ T cells are enriched in liver and embrace hepatitis B virus (HBV)-specific T cells in chronic hepatitis B (CHB) patients, their roles in disease progression remain poorly understood. This study aimed to decipher their profiling and dynamic changes during chronic HBV infection.

Methods

Blood samples from 257 CHB patients and nontumor liver specimens from 73 HBV-positive patients were analyzed for CD161⁺CD8⁺ T-cell characterization by flow cytometry, TCR

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10060787 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature