Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression.

ABSTRACT:

Introduction

The lateral habenula (LHb) is a promising deep brain stimulation (DBS) target for treatment-resistant depression (TRD). However, the optimal surgical trajectory and its safety of LHb DBS are lacking.

Methods

We reported surgical trajectories for the LHb in six TRD patients treated with DBS at the General Hospital of the Chinese People's Liberation Army between April 2021 and May 2022. Pre-operative fusions of magnetic resonance imaging (MRI) and computed tomography (CT) were conducted to design the implantation trajectory of DBS electrodes. Fusions of MRI and CT were conducted to assess the safety or precision of LHb DBS surgery or implantable electrodes locations.

Results

Results showed that the optimal entry point was the posterior middle frontal gyrus.

SUBMITTER: Cui Z 

PROVIDER: S-EPMC10060811 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature