Accuracy of Raman spectroscopy in the diagnosis of Alzheimer's disease.

ABSTRACT:

Objective

To systematically evaluate the accuracy of Raman spectroscopy in the diagnosis of Alzheimer's disease.

Methods

Databases including Web of Science, PubMed, The Cochrane Library, EMbase, CBM, CNKI, Wan Fang Data, and VIP were electronically searched for studies on Raman spectroscopy in diagnosis of Alzheimer's disease from inception to November 2022. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias in the included studies. Then, meta-analysis was performed using Meta-Disc1.4 and Stata 16.0 software.

Results

A total of eight studies were finally included. The pooled sensitivity of Raman spectroscopy was 0.86 [95% CI (0.80-0.91)], specificity was 0.87 [95% CI (0.79-0.92)], positive likelihood ratio was 5.50 [95%

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10060832 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature