Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo.

ABSTRACT:

Introduction

To achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulator of TCR signaling, shapes this 'activation-suppression' balance by modulating Tcon cell resistance to Treg-mediated suppression. Treg cells also express SHP-1, but its role in influencing Treg function is still not fully understood.

Methods

We generated a Treg-specific SHP-1 deletion model, Foxp3^Cre+ Shp-1^f/f , to address how SHP-1 affects Treg function and thereby contributes to T cell homeostasis using a combination of ex vivo studies and in vivo models of inflammation and autoimmuni

SUBMITTER: Gu Q 

PROVIDER: S-EPMC10060847 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature