Conserved but not critical: Trafficking and function of Na_V1.7 are independent of highly conserved polybasic motifs.

ABSTRACT: Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (Na_V) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that detect and transduce noxious stimuli. Na_V1.7 sets the gain on peripheral pain-signaling neurons and is the best validated peripheral ion channel involved in human pain, and previous work has shown that it is transported in vesicles in sensory axons which also carry Rab6a, a small GTPase known to be involved in vesicular packaging and axonal transport. Understanding the mechanism of the association between Rab6a and Na_V1.7 could inform therapeutic modalities to decrease trafficking of Na_V1.7 to the dist

SUBMITTER: Tyagi S 

PROVIDER: S-EPMC10060856 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature