Inhibition of melanoma using a nanoceria-based prolonged oxygen-generating phototherapy hydrogel.

ABSTRACT: Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO₂) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO₂) with infiltrated H₂O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO₂ could efficiently allevi

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10060878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature