Single-cell transcriptome profiling reveals enriched memory T-cell subpopulations in hypertension.

ABSTRACT: Introduction: The adaptive immune response mediated by T cells plays a vital role in the initiation and maintenance of blood pressure (BP) elevation. Memory T cells, which are antigen-specific T cells, can respond specifically to repeated hypertensive stimuli. Although the roles of memory T cells in animal models are well studied, their maintenance and functions in hypertensive patients are poorly understood. Method: Here, we focused on the circulating memory T cells of hypertensive patients. By using single-cell RNA sequencing technology, subsets of memory T cells were identified. Differentially expressed genes (DEGs) and functional pathways were explored for related biological functions in each population of memory T cells. Result and Discussion: Our study identified

SUBMITTER: Wang X 

PROVIDER: S-EPMC10060952 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature