Association of proton pump inhibitors with gastric and colorectal cancer risk: A systematic review and meta-analysis.

ABSTRACT: Background: Proton pump inhibitors (PPI) are generally considered to be one of the well-established prescription drug classes and are commonly used to treat most acid-related diseases. However, a growing body of literature showing an association between gastric and colorectal cancer risk and PPI use continues to raise concerns about the safety of PPI use. Therefore, we aimed to investigate the association between proton pump inhibitor use and risk of gastric and colorectal cancer. Methods: We collected relevant articles using PubMed, Embase, Web of Science and Cochrane library from 1 January 1990 to 21 March 2022. The pooled effect sizes were calculated based on the random-effects model. The study was registered with PROSPERO (CRD42022351332). Results: A total of 24 st

SUBMITTER: Guo H 

PROVIDER: S-EPMC10060974 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature