Fucosylated TLR4 mediates communication between mutualist fucotrophic microbiota and mammalian gut mucosa.

ABSTRACT:

Objective

The glycans on the mucosa of suckling mice are predominantly sialylated; upon weaning, fucosylated glycans preponderate. This manifestation of mutualism between fucotrophic bacteria and the mature host utilizes a sentinel receptor in the intestinal mucosa; this receptor was isolated to distinguish its structural and functional features.

Design

Provisional identification of the sentinel gut receptor as fuc-TLR4 was through colonization of germ-free mutant mice. Conventional mice whose microbiota was depleted with a cocktail of antibiotics were used to further define the nature and functions of fuc-TLR4 sentinel, and to define the role of the fucotrophic microbiota in gut homeostasis and recovery from insult. The nature of the sentinel was confirmed in cultured human

SUBMITTER: Nanthakumar NN 

PROVIDER: S-EPMC10061023 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature