Evolution of visual guanylyl cyclases and their activating proteins with respect to clade and species-specific visual system adaptation.

ABSTRACT: Membrane guanylyl cyclase receptors are important regulators of local cGMP production, critically influencing cell growth and differentiation as well as ion transport, blood pressure and calcium feedback of vertebrate phototransduction. Currently, seven different subtypes of membrane guanylyl cyclase receptors have been characterized. These receptors have tissue specific expression and are activated either by small extracellular ligands, changing CO₂ concentrations or, in the case of visual guanylyl cyclases, intracellularly interacting Ca²⁺-dependent activating proteins. In this report, we focus on the visual guanylyl cyclase receptors (GCs) GC-E (gucy2d/e) and GC-F (gucy2f) and their activating proteins (GCAP1/2/3; guca1a/b/c). While gucy2d/e

SUBMITTER: Gesemann M 

PROVIDER: S-EPMC10061024 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature