Isolated anti-Ro52 identifies a severe subset of Sjogren's syndrome patients.

ABSTRACT:

Introduction

Serum autoantibodies targeting the SSA/Ro proteins are a key component of the classification criteria for the diagnosis of Sjögren's syndrome (SS). Most patients' serum reacts with both Ro60 and Ro52 proteins. Here we compare the molecular and clinical characteristics of patients diagnosed with SS with anti-Ro52 in the presence or absence of anti-Ro60/La autoantibodies.

Methods

A cross-sectional study was performed. Patients in the SS biobank at Westmead Hospital (Sydney, Australia) that were positive for anti-Ro52 were included and stratified based on the absence (isolated) or presence (combined) of anti-Ro60/La, measured by line immunoassay. We examined clinical associations and the serological and molecular characteristics of anti-Ro52 using ELISA and mass sp

SUBMITTER: Lee AYS 

PROVIDER: S-EPMC10061105 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature