The right ventricle in tetralogy of Fallot: adaptation to sequential loading.

ABSTRACT: Right ventricular dysfunction is a major determinant of outcome in patients with complex congenital heart disease, as in tetralogy of Fallot. In these patients, right ventricular dysfunction emerges after initial pressure overload and hypoxemia, which is followed by chronic volume overload due to pulmonary regurgitation after corrective surgery. Myocardial adaptation and the transition to right ventricular failure remain poorly understood. Combining insights from clinical and experimental physiology and myocardial (tissue) data has identified a disease phenotype with important distinctions from other types of heart failure. This phenotype of the right ventricle in tetralogy of Fallot can be described as a syndrome of dysfunctional characteristics affecting both contraction and filling. The

SUBMITTER: Alipour Symakani RS 

PROVIDER: S-EPMC10061113 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature