Urinary proteome profiles associated with cognitive decline in community elderly residents-A pilot study.

ABSTRACT: Non-invasive and simple methods enabling easy identification of individuals at high risk of cognitive decline are needed as preventive measures against dementia. This pilot study aimed to explore protein biomarkers that can predict cognitive decline using urine, which can be collected non-invasively. Study subjects were selected from participants in a cohort study of middle-aged and older community-dwelling adults who underwent cognitive testing using the Mini-Mental State Examination and provided spot urine samples at two time points with an interval of approximately 5 years. Seven participants whose cognitive function declined 4 or more points from baseline (Group D) and 7 sex- and age-matched participants whose cognitive function remained within the normal range during the same period (

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC10061132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature