Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study.

ABSTRACT:

Background

The serum metabolome is a potential source of molecular biomarkers associated with the risk of breast cancer. Here we aimed to analyze metabolites present in pre-diagnostic serum samples collected from healthy women participating in the Norwegian Trøndelag Health Study (HUNT2 study) for whom long-term information about developing breast cancer was available.

Methods

Women participating in the HUNT2 study who developed breast cancer within a 15-year follow-up period (BC cases) and age-matched women who stayed breast cancer-free were selected (n=453 case-control pairs). Using a high-resolution mass spectrometry approach 284 compounds were quantitatively analyzed, including 30 amino acids and biogenic amines, hexoses, and 253 lipids (acylcarnitines, glycerides

SUBMITTER: Mrowiec K 

PROVIDER: S-EPMC10061137 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature