Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia.

ABSTRACT:

Background

Acetaminophen has been evaluated in horses for treatment of musculoskeletal pain but not as an antipyretic.

Objectives

To determine the pharmacokinetics and efficacy of acetaminophen compared to placebo and flunixin meglumine in adult horses with experimentally induced endotoxemia.

Animals

Eight university owned research horses with experimentally induced endotoxemia.

Methods

Randomized placebo controlled crossover study. Horses were treated with acetaminophen (30 mg/kg PO; APAP), flunixin meglumine (1.1 mg/kg, PO; FLU), and placebo (PO; PLAC) 2 hours after administration of LPS. Plasma APAP was analyzed via LC-MS/MS. Serial CBC, lactate, serum amyloid A, heart rate and rectal temperature were evaluated. Serum IL-1β, IL-6, IL-8, IL-10, and TNF-α were

SUBMITTER: Mercer MA 

PROVIDER: S-EPMC10061170 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature