Retrospective analysis of immunosuppressive and anti-thrombotic protocols in nonassociative immune mediated hemolytic anemia in dogs.

ABSTRACT:

Background

Evidence supporting the effectiveness of therapeutic protocols for nonassociative immune-mediated hemolytic anemia (na-IMHA) is weak.

Hypothesis/objectives

Investigate the efficacy of various drugs in na-IMHA.

Animals

Two hundred forty-two dogs.

Methods

Multi-institutional retrospective study (2015-2020). Immunosuppressive effectiveness was determined by time to packed cell volume (PCV) stabilization and duration of hospitalization through analysis by mixed model linear regression. Occurrence of disease relapse, death, and antithrombotic effectiveness, were analyzed using mixed model logistic regression.

Results

Use of corticosteroids vs a multi-agent protocol had no effect on time to PCV stabilization (P = .55), duration of hospitalization (P

SUBMITTER: Weng J 

PROVIDER: S-EPMC10061171 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature